I was diagnosed with a propylene glycol allergy via skin patch testing. Propylene glycol is a recognized source of both allergic and irritant contact dermatitis. In a repeated insult patch test of 104 persons, propylene glycol was studied under occlusion for an indication of allergy. Propylene glycol and polyethylene glycol ingredients well worth avoiding there are many nasty ingredients out there, but in this post i want to touch on two that i find particularly bad.
Patch testing for metal allergy with manufacturersupplied. Propylene glycol is a safe ingredient as long as it does not irritate or place discomfort on your skin. Propylene glycol is considered generally safe by the fda. Patch tests are used to identify the cause of contact allergic dermatitis. Patch tests were positive to zovirax cream, acyclovir, valacyclovir and propylene glycol.
The first induction patch was tested at 100% propylene glycol, which demonstrated some. Propylene glycol is also used in industry as an ingredient in brake fluid and antifreeze and as a humectant in tobacco products. Incidence of positive patch tests to propylene glycol. The nacdg uses a 30% concentration when patch testing propylene glycol. This allergy is typically diagnosed by patch testing. Methods two pe patients were referred for preoperative patch testing with the metal disc to screen for metal. Your patch testing results indicate that you have a contact allergy to propylene glycol. I am so thankful the allergist i found knew something about this tricky diagnosis. If you have purchased a new product you should test it on a small skin area to. I periodically get eczema and back in the 1990s and early 2000s keri lotion had propylene glycol in it. It is a solvent for fats, oils, waxes, resins, flavoring extracts, perfumes, colors, softdrink syrups, and antioxidants. Further evidence for a true immunological reaction has been provided by the observation of. Because it is a strong irritant, patch test reactions should be judiciously evaluated, and multiple tests with serial dilutions should be considered.
Propylene glycol is a compound which is generally recognized as safe gras by the u. Polyethylene glycol 400 peg 400 chemotechnique diagnostics. Allergic contact dermatitis to topical minoxidil solution. It primarily functions as a vehicle, solvent, or emulsifier in cosmetics and topical medications. My skin problems, however, go back to june 20 when i was misdiagnosed with postmenopausal atrophic vaginitis. It was a life changing diagnosis for me make sure your skin patch testing is done correctly. I was diagnosed with my propylene glycol pgpolyethylene glycol peg allergy by patch testing in april 2014. Review by germanys paulehrlichinstitute pei is an ongoing process. There is a card database that dermatologists use that can generate lists of products that are safe to use for patients with this type of. Patch testing is a simple procedure to help diagnose allergic contact dermatitis and identify the causative agents. Test is a convenient, readytouse patch test for the diagnosis of allergic contact dermatitis. Test is an epicutaneous patch test indicated for use as an aid in the diagnosis of allergic contact dermatitis in persons 6 years of age and older whose history suggests sensitivity to one or more of the 35 substances included on the t.
The aim of the study was to report incidence of positive patch tests to pg at mayo clinic. Infants and pregnant women propylene glycol enters the body as an alcohol and metabolizes in the bodys enzyme pathways. For patch testing, the concentration of pg must be high enough to. To characterize the prevalence of positive patchtest reactions to pg and the epidemiology of affected patients.
Part 1 of this article series focuses on patch test kits, choosing the right patient. After all, propylene glycol is the most common allergen found in cortiosteroids and is found in 65% of the topical steroid medications on the market, while being more common in branded ointment and gels. Glycol and battery tester ethylene glycol, propylene. Test is an epicutaneous patch test indicated for use as an aid in the diagnosis of allergic contact dermatitis in persons 6 years of age and older whose history suggests sensitivity to one or more of the 36 substances included on the t. Chemical product and company identification product name. Sierra antifreeze or coolant is formulated with pg rather than ethylene glycol the base for traditional antifreeze. Basics of patch testing for allergic contact dermatitis. Part 1 provides information on patch test kits, choosing the right patient, selecting an adequate screen and suspect allergens, accepting test limitations, and supplemental panels. Test is an epicutaneous patch test indicated for use as an aid in the. Thus, one study of particular interest is a postmarketing survey of the true test that compiled data from sources in. Propylene glycol allergy historically difficult to. This contact allergy may cause your skin to react when it is exposed to this substance although it may take several days for the symptoms to appear. Propylene glycol is also used as a coolant in refrigeration systems.
Your patch test result indicates that you have a contact allergy to propylene glycol. Systemic contact dermatitis can be due to propylene glycol found in foods, especially salad dressings. I used my radiator tester with the five floating balls, and none of them floated. Patch and prick tests with famciclovir were negative, but its oral administration caused an itchy. Propylene glycol is common in skin care products and is associated with both allergic and irritant patch test reactions. Test antifreeze, engine coolants, and heattransfer fluids. Propylene glycol is a viscous, colorless, virtually odorless alcohol and is widely used for its solvent, humectant. Peak is the pioneer and market leader in the safer propylene glycol pg antifreeze category.
Propylene glycol pg may cause allergic or irritant contact dermatitis. Not all products labeled as natural are free from propylene glycol. Polyethylene glycol as a cause of anaphylaxis allergy. Polyethylene glycol is a condensation polymers of ethylene oxide and water with the general formula hoch2ch2noh, where n is the average number of repeating. Many of the allergeaze allergens have already been licensed by pei, while remaining. Antifreeze tester hand held antifreeze tester balkamp. Allergen number showing its position on the panel is shown in brackets. I think the mechanic put propylene glcol in the radiator instead of ethylene glycol. Propylene glycol 1,2dihydroxypropane or 1,2propanediol or methyl glycol or trimethyl glycol is a water soluble alcohol and it is a clear liquid used in antifreeze and deicing solutions for cars, airplanes, and boats. Baseline series of patch test allergens dermnet nz. The entire patchtest process generally requires 5 to 7 days, depending on the clinic. If you do read labels, finding our youre allergic to propylene glycol could send you into a bit of a tailspin. The goal is for physicians to both add and search for information regarding specific allergens and topics.
Food and drug administration fda under 21 cfr x184. These pathways do not mature in humans until 12 to 30. Organic synthesis, especially for polypropylene glycol and polyester resins. Propylene glycol personal care products, cosmetics preservative, humectant, emollient, and spreader. Typical symptoms include redness, swelling, itching, and fluidfilled blisters. Patch test studies with propylene glycol pg in dermatological patients. Propylene glycol p019b, p019a your patch testing results indicate that you have a contact allergy to propylene glycol. Paradigms for elicitation thresholds for allergic and irritant contact dermatitis have been described.
Dip the strip in the test substance to indicate the boiling point, freezing point and ph. Test is sold in boxes of 5 patch test units 5 each of panel 1. This concept is evident in previous patch test studies,69 in which increasing concentrations of propylene glycol are less well tolerated. This 2part series discusses improving patch test efficacy.
Propylene glycol pg is a solvent, vehicle, and humectant being used increasingly in a wide array of personal care products, cosmetics, and topical medicaments. However, the efficacy of this disc is not well understood. All allergeaze allergens are manufactured by a gmpcertified pharmaceutical company in accordance with guidelines on good manufacturing practices gmp and good laboratory practices glp. User allergic contact dermatitis story submitted on 22316. The physician who performed the test can provide resources to help with avoidance measures. It is important that you familiarize yourself with this chemical and take steps to avoid coming in contact with it. Most of the time, propylene glycol does not accumulate in your body, as it breaks down within 48 hours of ingestion or exposure.
The aim of the study was to report incidence of positive patch tests to pg at mayo. In a recent study by the north american contact dermatitis group nacdg, personal care products were found to be the most common sources of exposure to propylene glycol 53. Common allergens found in topical cortisone could they. Objective the purpose of this study was to determine the sensitivity of the metal disc in detecting nickel allergy compared with that of standard patch testing. Propylene glycol causes allergic reactions in some patients. Als environmental does not sell chemicals, but offers analytical lab testing to determine the presence of various elements and chemical compounds. The contact dermatitis institute allergen database was designed as a wikilike resource for information regarding allergic contact dermatitis. Propylene glycol pg is a viscous dihydric alcohol widely used as a vehicle for topical medications and cosmetics. Use cooltrak coolant test strips to test a sample of ethylene or propylene glycol based coolants. If youre not used to reading ingredient labels, a positive patch test to propylene glycol might not mean much to you.
Different types of macrogol exist according to their molecular weight from 300 gmol to 10,000,000 gmol. Several patchtest studies in different test populations with propylene glycol in concentrations between 2 and 30% revealed a frequency of positive reactions in a range of 0. It may cause a variety of mild to moderate side effects in humans. High aerosol concentrations may cause mild irritation of. It is important that you it is important that you familiarize yourself with this chemical and take steps to avoid coming in contact with it. Be sure to pay close attention to product labels the next time you are shopping for products that are propylene glycol free. Propylene glycol is used in organic synthesis, especially polypropylene glycol, poly est er resins, cellophane and antifreeze solutions. If i use lotions and creams they just seem to burn my skin if i put it on the eczema. A retrospective chart analysis of all patients patch tested for evaluation of facial dermatitis. Increased concentrations were associated with increased reactions. Propylene glycol is also present in propylene glycol alginate, which is known as e405. Despite the fdas milquetoast evaluation of propylene glycol, there are several other health concerns, including. Your patch testing results indicate that you have a contact allergy to propylene. The original true test consisted of 23 allergens and one control that could be.
Get deals on automotive parts, truck parts and more. Buy antifreeze tester hand held antifreeze tester balkamp bk 7761026 online from napa auto parts stores. Patch testing in allergic contact dermatitis from minoxidil. Propylene glycol p019b your patch testing results indicate that you have a contact allergy to propylene glycol. These difficulties should be kept in mind when considering the reports on allergic contact dermatitis or positive patch test reactions to pg in the following sections. Skinsensitizing and irritant properties of propylene glycol. In conclusion, on the basis of both the literature and our experience, firstline patch testing should include challenges with the minoxidil preparation as is, minoxidil in propylene glycol if. It is widely used as an additive in pharmaceuticals, cosmetics and food. There must be a tester for propylene glycol, but what if i mix them. Propylene glycol and polyethylene glycol ingredients. Polyethylene glycol peg or macrogol is a polyether compound.
Propylene glycol is used as a softening agent, preservative, humectant, and solvent in cosmetics, fragrances, topical medications. Allergen database contact dermatitis institute leaders. Because of its pg formula, sierra antifreeze is less toxic and therefore safer for people, pets and wildlife than conventional antifreeze. Smartpractice dermatology skin patch testing supplies for diagnosis of allergic contact dermatitis with t. Fahrenheit refractometer for testing ethylene glycol freezing point, propylene glycol freeze point, and the state of charge in leadacid batteries. Since propylene glycol has a density much closer to water, the ethylene glycol tester didnt work. Propylene glycol allergeaze contact dermatitis allergens.
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